your offspring and her offspring. Humanity is now divided into two communities: the redeemed, who love God, and the reprobate, who love self (John 8:33, 44; 1 John 3:8). The division finds immediate expression in the hostility of Cain against Abel (ch. 4). This prophecy finds ultimate fulfillment in the triumph of the Second Adam, and the community united with Him, over the forces of sin, death, and the devil (Dan. 7:13, 14; Rom. 5:12–19; 16:20; 1 Cor. 15:45–49; Heb. 2:14, 15).
bruise . . . bruise. Before His glorious victory, the woman’s Seed must suffer to win the new community from the serpent’s dominion (Is. 53:12; Luke 24:26, 46; 2 Cor. 1:5–7; Col. 1:24; 1 Pet. 1:11).
head . . . heel. The suffering Christ is victorious. He has already won the victory at the Cross by providing an atonement for the saints (Col. 2:13–15) and will consummate it at His Second Coming (2 Thess. 1:5–10)."
Note from the Reformation Study Bible on Genesis 3:15